BEGIN:VCALENDAR PRODID:-//Microsoft Corporation//Outlook 16.0 MIMEDIR//EN VERSION:2.0 METHOD:PUBLISH X-MS-OLK-FORCEINSPECTOROPEN:TRUE BEGIN:VTIMEZONE TZID:W. Europe Standard Time BEGIN:STANDARD DTSTART:16011028T030000 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10 TZOFFSETFROM:+0200 TZOFFSETTO:+0100 END:STANDARD BEGIN:DAYLIGHT DTSTART:16010325T020000 RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3 TZOFFSETFROM:+0100 TZOFFSETTO:+0200 END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT CLASS:PUBLIC CREATED:20260415T145249Z DESCRIPTION:This is the way: Bringing long-read data analysis to clinical r outine\nWhen? June 13 | 12:15 -13:30 (CEST)\nWhere? Room A4 \nLong-read s equencing has emerged as a powerful and comprehensive approach for whole-g enome analysis\, enabling high-resolution characterization of complex\, re petitive\, and otherwise challenging genomic regions. By overcoming key li mitations of traditional short-read and stepwise diagnostic workflows\, lo ng-read technologies offer a cost-effective and time-efficient alternative capable of consolidating multiple assays into a single test. \nHowever\, the adoption of long-read sequencing in routine diagnostics remains constr ained by the substantial bioinformatics\, IT\, and regulatory expertise an d effort required to manage the fragmented RUO analysis pipelines. \nTo fu lly leverage the diagnostic potential of long read sequencing\, laboratori es – especially smaller labs with limited resources – require standard ized\, end-to-end software solutions that deliver robust data processing\, intuitive visualization of complex variant types\, and compliance with me dical device regulations.\nIn this Corporate Satellite session\, you will learn how the IVDR-certified varvis® software addresses these challenges by providing a streamlined\, medically validated platform that enables lon g-read sequencing as a first-line diagnostic approach. By integrating auto mated analysis with user-friendly interpretation tools\, the varvis® soft ware facilitates efficient\, comprehensive\, and scalable genomic diagnost ics\, supporting laboratories in advancing diagnostic quality and yield.\n Part 1 — A Hitchhiker’s Guide to LRS: Implementing long-read sequencin g in clinical diagnostics\nDr. Denny Schanze\, University Hospital Magdebu rg\nIn this talk\, Denny Schanze will walk you step by step through his te am’s journey of establishing Nanopore Sequencing at the University Hospi tal Magdeburg with minimum in-house IT resources using the varvis® softwa re. He will present a selection of clinical examples illustrating the capa bilities\, challenges and practical benefits of the complete solution incl uding analysis of complex structural variants and repeat expansions.\nPart 2 — Beyond simple variant detection: Maximizing the clinical utility of long-read sequencing\nDr. Ben Liesfeld\, Limbus Medical Technologies GmbH \nLong-read sequencing offers clinical value beyond improved variant de tection. This talk highlights two types of information uniquely enabled by long reads that are difficult to obtain with short-read technologies. Fir st\, long reads allow accurate analysis of complex genomic regions\, inclu ding genes with highly homologous paralogs or pseudogenes. Second\, long-r ead sequencing provides native DNA methylation data without additional ass ays. Examples for both capabilities are demonstrated using the varvis® so ftware\, illustrating their potential for integrated genetic and epigeneti c diagnostics.\n \n DTEND;TZID="W. Europe Standard Time":20260613T133000 DTSTAMP:20260415T145249Z DTSTART;TZID="W. Europe Standard Time":20260613T121500 LAST-MODIFIED:20260415T145249Z LOCATION:Room A4 PRIORITY:5 SEQUENCE:0 SUMMARY;LANGUAGE=de:varvis® Corporate Satellite @ESHG 2026 - This is the w ay: Bringing long-read data analysis to clinical routine TRANSP:OPAQUE UID:040000008200E00074C5B7101A82E0080000000040061282F7CCDC01000000000000000 010000000AE319E5E3EBFDE47B6DC1C5296110581 X-ALT-DESC;FMTTYPE=text/html:

This is the way: B ringing long-read data analysis to clinical routine< /p>

When? June 13 | \;12:15 -13:30 (CEST)
< i>Where? Room A4 

Long-read sequencing has emerged as a powerful and comprehensive approach for whole- genome analysis\, enabling high-resolution characterization of complex\, r epetitive\, and otherwise challenging genomic regions. By overcoming key l imitations of traditional short-read and stepwise diagnostic workflows\, l ong-read technologies offer a cost-effective and time-efficient alternativ e capable of consolidating multiple assays into a single test.

However\, the adoption of long-read sequencing in routine diagnostics remains constrained by the substantial b ioinformatics\, IT\, and regulatory expertise and effort required to manag e the fragmented RUO analysis pipelines.

To fully leverage the diagnostic potential of long read se quencing\, laboratories –\; especially smaller labs with limited reso urces –\; require standardized\, end-to-end software solutions that d eliver robust data processing\, intuitive visualization of complex variant types\, and compliance with medical device regulations.

In this Corporate Satellite session\, you w ill learn how the IVDR-certified varvis® software addresses th ese challenges by providing a streamlined\, medically validated platform t hat enables long-read sequencing as a first-line diagnostic approach. By i ntegrating automated analysis with user-friendly interpretation tools\, th e varvis® software facilitates efficient\, comprehensive\, and scalable genomic diagnostics\, supporting laboratories in advancing diagn ostic quality and yield.

Part 1 —\; A Hitchhiker’\;s Guide to LRS: Implementing long-re ad sequencing in clinical diagnostics
Dr. Denny Schanze\, University Hospital Magdebu rg

In this talk\, Denny Schanze wil l walk you step by step through his team’\;s journey of establishing Nanopore Sequencing at the University Hospital Magdeburg with minimum in-h ouse IT resources using the varvis® software. He will present a selection of clinical examples illustrating the capabilities\, challenge s and practical benefits of the complete solution including analysis of co mplex structural variants and repeat expansions.

Part 2 —\; Beyond simple variant detection: Maximizing the clinical utility of long-read sequencing
Dr. Ben Liesfeld\, Limbus Medical Technologies GmbH  < /span> \;

Long-read sequencing offers clinical value beyond improved variant detection. This talk highlig hts two types of information uniquely enabled by long reads that are diffi cult to obtain with short-read technologies. First\, long reads allow accu rate analysis of complex genomic regions\, including genes with highly hom ologous paralogs or pseudogenes. Second\, long-read sequencing provides na tive DNA methylation data without additional assays. Examples for both cap abilities are demonstrated using the varvis® software\, illust rating their potential for integrated genetic and epigenetic diagnostics.< o:p>

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