NGS targeted panel analysis made ingeniously simple

The varvis® software enables you to identify rare and causative CNV, SNV and Indels in a single validated process and to replace conventional ligation-based screening method with one comprehensive approach. Automate your NGS workflow and reduce your turnaround time to minutes!

 

A clinical decision support system – made for use in diagnostic procedures

 

Onboarding, IT and support services included

Validated CNV analysis for clinical diagnostics

Our automated and clinically validated CNV analysis is completely integrated into the NGS workflow. In parallel to SNVs and Indels, copy number variants are detected automatically by our bioinformatics pipeline. Performance validation with your own data is provided as a service, so you can be sure to use the varvis® software as an effective and reliable screening tool in clinical routine.

  Trust your results

The quality of the CNV data is proven to be compliant with all relevant standards regarding NGS validation.

  Reduce your turn-around time

For most patients the result of the CNV analysis is immediately available without an additional confirmation.

  One for all

Our CNV analysis is available for all genes and insensitive to SNPs.

   Supreme expert support

Our team provides first-class support regarding workflow optimization, technical issues, training and documentation – even for the tricky cases. We are here to help!

Our CNV detection algorithm was validated using thousands of clinical samples. In this example, more than 400 consecutive samples from routine diagnostics were analyzed with our bioinformatics CNV pipeline and the results were compared to gold-standard PCR-based methods to confirm the results for every single probe/target region. The numbers represent typical results that are achieved for validation: 

100% sensitivity

All variants identified with PCR-based methods were also detected by our bioinformatics pipeline.

>99% specificity

Due to a very low false-positive rate, the varvis® CNV analysis is a very effective and reliable screening tool.

80% cost and time savings

Replace multiple expensive assays with a single comprehensive approach.

A clincial decision support system
made for use in clinical diagnostics

The varvis® software is designed to deliver the optimum workflow for genetic testing labs and to make variant interpretation as reliable, fast and easy as possible. Cloud-native CE medical device software

Automate your NGS workflow

To really leverage all varvis® software features across your entire laboratory workflow, integration into your other software systems is key.

Build and utilize your own variant database

Systematically collect all variant data in a high-performance structured database and, at the same time, augment your data with high-quality data from all other users on our platform.

ACMG compliant classification

Interpret causative variants in concordance with the ACMG standards and store the evidence as part of your varvis® knowledgebase.

Features

Virtual panels

Quickly construct virtual panels that contain your genes of interest.

Validated CNV analysis

Validated CNV analysis

Increase your diagnostic yield by utilized our validated CNV analysis.

Annotations

Review all relevant variant annotation at a glance

Annotations
Coverage histogram

Coverage histogram

Receive immediate QC feedback about samples/regions failing quality thresholds such as low coverage regions to optimize your lab process.

Support and software as a service

Our dedicated expert service team provides first class support regarding workflow optimization, technical support, training, documentation as well as validation following all relevant international guidelines.

 
No investment in IT
infrastructure

You initiate raw data upload by pushing a button. We deal with IT, processing and bioinformatics.

 
NGS validation as a service

Just sequence the appropriate reference samples – we take care of the rest. Regular updates are included!

 
Cloud-native CE medical device software

Focus on diagnostics. We are certified so you can trust the software you are using.

 
Overnight express

 No matter how many samples or how many sequencing runs you have: our fully automated process delivers results overnight. Guaranteed.

On-boarding made simple – we get you all set up within a week!

Get in touch and see for yourself

Request a demo

Read more

The varvis® API facilitates integration and automation of your workflows

by Ben Liesfeld, Jan 7, 2020

We design varvis to deliver the optimum workflow for genetic testing labs. To really leverage all varvis features across your entire laboratory workflow, integration into your other software systems is key.
 

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NGS validation as a service

NGS validation as a service

 

by Ben Liesfeld, Nov 14, 2017

Every clinical lab is facing challenges when validating NGS assays. An automated validation process on the varvis® platform make this as simple as possible for our customers.
 

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The new ACMG calculator in varvis®
 

by Yvonne Kasmann, Dec 18, 2019

varvis® now facilitates clinical variant interpretation in concordance with the ACMG standards and guidelines. The evidence for classification becomes part of your varvis knowledge base.
 

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