Whole exome analysis in clinical diagnostics
The varvis® software is purpose-built for efficient whole exome analysis. Our CNV analysis has undergone rigorous performance evaluation, offering single-exon resolution and built-in QC monitoring, enabling confident replacement of traditional CNV detection methods. Use intuitive filtering options and analyze whole exomes in minutes with the varvis® software.
Automated IT
and data processing
SNV and CNV analysis with proven performance for clinical genetics
Rapid variant interpretation and classification
The varvis® whole exome service
With high-performance target enrichment and reduced sequencing costs, exome sequencing has become a practical and powerful first lifirst-linene diagnostic tool. While generating sequencing data has become easier and more affordable than ever, establishing, optimizing, and evaluating the performance of data analysis workflows remains a challenge. With the varvis® software, you get both a comprehensive software and the expert support you need — as a service.
Cloud-native medical device software certified as Class C under IVDR
Focus on diagnostics. We are certified so you can trust the software you are using and the results you report.
Don’t worry about IT
You initiate raw data upload by pushing a button. We deal with IT, processing and bioinformatics. Our fully automated process delivers results within hours - even overnight. Guaranteed.
Performance test reports – as a service
Just sequence the appropriate reference samples – we take care of the rest. Regular updates are included!
Supreme expert support
Our dedicated expert service team provides first class support regarding workflow optimization, technical issues, training and documentation. We are here to help!
Replace conventional Del/Dup detection methods with NGS
Utilize the rich information that NGS provides. Our unique CNV analysis with proven performance, featuring single-exon resolution and integrated QC monitoring, enables you to confidently replace conventional CNV detection methods.
Seamless & automated data analysis workflow
From QC monitoring to variant classification and reporting – the varvis® software supports the complete analysis workflow. Automated CNV and SNV analyses with proven performance are fully integrated into the process. All variants are comprehensively annotated and immediately available for your review within the varvis® software.
Centralized annotation service
The varvis® software provides regularly updated annotation sources that are relevant for clinical diagnostics, like ClinVar. Overwhelmed by the new information pouring in every month? Our automated alerts that focus on variants relevant to your patients enable you to keep all your reports up-to-date!
Build your own variant database
Systematically collect all genomic data in a high-performance structured database including genotype, phenotype and segregation data. Know your own patient cohort, know your artefacts, and systematically utilize this valuable information.
At the same time, augment your data with high-quality data from all other users on our platform
Do you need more than 15 minutes to interpret a whole exome?
Accelerate WES interpretation by combining phenotype, family and inheritance information
Virtual panels
Quickly construct and easily manage virtual panels containing genes of interest and combine them with filters to focus on the variants that matter.
Inheritance patterns
Accelerate interpretation of trios or more complex families using built-in inheritance filters. Count on automated selection of relevant patterns based on genotype and affection status.
HPO manager
Capture your patient’s clinical picture in detail and easily browse the HPO hierarchy. Easily browse the HPO hierarchy and capture your patient’s clinical picture in detail. This step enables calculation of HPO similarity score and boosts variant prioritization. In addition, you can also get a glimpse of genes and diseases associated with every term.
University of Magdeburg
University of Leipzig
Synlab Zentrum für Humangenetik Mannheim
University of Göttingen
Gemeinschaftspraxis für Humangenetik & Genetische Labore Hamburg
See for yourself how the varvis® software can accelerate your laboratory workflows
and increase your diagnostic yield.
Read more
Huntington’s disease: from understanding repeat instability to editing the genetic code
by Roberta Trunzo, April 14, 2026
Huntington’s disease (HD) has long been known as a genetic disorder caused by CAG repeat expansions in the HTT gene. Recent discoveries have reshaped our understanding — and, for the first time, offered a way to intervene at the genetic level.
Update to gnomAD v4.1: Key features
by Roberta Trunzo, August 27, 2024
The varvis® software now includes the latest version of the Genome Aggregation Database (gnomAD), providing updated annotations for whole exome and whole genome data. This article describes the enhancements and implications of the update to the new version 4.1, particularly for clinical diagnostics.
The varvis® Software: The first genomics end-to-end software certified as IVDR Class C device
by Dr. Ben Liesfeld, May 31, 2024
Genetic diagnostic laboratories now have access to the first complete genomics software solution which is certified as a Class C device under IVDR. This will significantly reduce the effort required for legally compliant documentation of in-house tests.