AI-powered variant interpretation with the AION integration
Limbus has teamed up with Nostos to combine the comprehensive long- and short-read analysis with the varvis® software and AI-powered variant interpretation and classification with AION. This collaboration unites two IVDR Class C-certified solutions – a unique combination in the field of genomic diagnostics. Together, they provide complete and scalable data analysis where it matters most, benefiting clinical professionals and patients alike.
Built for short and longs reads
Analyze both data types in one unified platform – no need for multiple tools
Now integrated with AION
AI-powered variant prioritization & automated ACMG classification
Certified
CE-IVD certificate to meet regulatory standards and support patient diagnostics
Truly hands-free
Automated IT, data processing and quality control – no manual setup needed
All-in-one
SNV, CNV, STR & SV analysis with proven analytical performance
One-for-all
From challenging dark regions to whole genomes, support any use case – at scale.
How it works with Aion
Powered by artificial intelligence, AION is built to assist you in interpreting genetic variants and prioritizing those most likely tied to disease. It is fast, easy to set up, certified as Class C under IVDR, and now fully integrated with the varvis® software.
AI-powered variant prioritization within your grasp:
Transfer genetic and clinical patient data to AION with just a click.
Get a shortlist of the most relevant variants,
including the associated diseases in only 10 - 30 minutes.
Select the relevant variants and receive a full
report with all key information.
Variant shortlists by AION
Find variants automatically identified as the most relevant in the AION results view.
Dual-model prioritization for small variants is ready for you:
AION Smoking guns
The most stringent list of strong diagnostic candidates, where all available evidence consistently points to their potential as disease-causing candidates for the case: The Smoking Guns detection is optimized for specificity where applicable, giving you an easy start into a case.
AION Clues
A full list of potential candidates with an indication of potential pathogenicity for the case: AION Clues is optimised for sensitivity, and aims to provide potential disease-causing candidates even for the hardest of cases.
„The adoption of AION allowed us to accelerate our diagnostics workflow. By enabling us to quickly identify disease-causing variants in genes matching the clinical description of our patients, we are able to complete the analysis in 1 hour for cases that previously would have taken several days.“
Dr. Valentina Ferradini
Tor Vergata Università Degli Studi di Roma
The future is now!
Unlock the full potential of AI-powered variant interpretation with AION. Elevate your analysis and uncover deeper insights from your genetic data with the varvis® software. Get in touch and benefit from the full potential of both platforms.