Focus on diagnostics -
We take care of the rest

The varvis®  software is CE-IVD certified for all clinical NGS applications, from NGS panels and WES to WGS. It is a complete solution for clinical diagnostics, supporting NGS raw data processing, genomics data management, and variant interpretation - making it the first genomics end-to-end software certified as Class C under IVDR. 

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IT infrastructure and
automated data processing

 
Validated SNV and CNV analysis for clinical genetics

 
Rapid variant interpretation
and classification

Solution

The varvis® genomics software is a complete solution for clinical diagnostics, supporting NGS raw data processing, genomics data management, and variant interpretation. Automated CNV and SNV analysis are clinically validated and completely integrated into the NGS workflow.

varvis genomics platform - Bioinformatics pipeline

Bioinformatics

Automated. Validated. Fast.

Our bioinformatics pipeline automates the processing of raw next-generation sequencing data from bcl, fastq, or bam files. On completion of all bioinformatics analyses, including alignment and clinically validated CNV/SNV/Indel variant calling, all results are annotated and visualized in the varvis® software automatically. Pipeline validation is provided as a service – updates are included.

varvis genomics software

varvis® genomics software

Made for use in clinical diagnostics

The varvis® software is a clinical decision support system (CDS) and allows you to review, filter, and classify genetic variants. In addition, it includes your own comprehensive variant database. It supports the clinical decision-making process and is the first genomics end-to-end software certified as IVDR Class C device.

varvis genomics platform - Annotation

Annotation

Always up to date

Our reference database, allexes®, provides the data for variant annotation to the varvis® software. The allexes® database does not only deliver the most recent versions of public databases, but also provides access to aggregated genomic reference data from all our users while continuing to be compliant with HIPAA and EU regulations.

Key benefits

 
Automated QC

Important quality metrics are monitored automatically for every single NGS sample, but also across batches over time. Don't waste a moment on manual QC.

 
80% savings

Our clinically validated CNV analysis provides significant time and cost savings compared to ligation based CNV detection methods.

  
Supreme expert support

Our dedicated team provides first-class support regarding workflow optimization, technical issues, training and documentation – even for the tricky cases. We are here to help!

   
NGS validation as a service

Simply sequence the appropriate reference sample to validate your workflow – we take care of the rest and provide you with a validation report. Regular updates are included.

Use cases

varvis genomics platform use case - NGS panels

NGS panels

Identify rare and causative SNV and CNV in a single validated process and replace conventional PCR-based methods.

varvis genomics platform use case - whole exome sequencing

Whole exome
sequencing

Do you need more than 15 minutes to interpret a whole exome? Accelerate WES interpretation by combining phenotype, family and inheritance information.

varvis genomics platform use case - liquid biopsy

Liquid biopsy

Detect somatic variants with validated high sensitivity using state-of-the-art molecular barcoding technologies.

varvis genomics platform use case - carrier screening

Carrier screening

Even the most complex scenarios are well covered in a single carrier screening filter to solve your cases with just a few clicks.

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Testimonials

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Limbus demonstrated the clinical validity of its varvis® CNV detection algorithms. We now use the varvis® CNV analysis as a very cost-effective and sensitive first-line diagnostics.
Prof. Martin Zenker, MD
University of Magdeburg
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The varvis® software has been designed from the start with the medical application in mind. The platform conveniently supports our diagnostic workflow. The service is excellent and the team is very reliable. The list of features is growing surprisingly fast.
Prof. Rami Jamra, MD
University of Leipzig
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Thank you for your excellent support with our platform validation. Based on the meaningful report you provided, I was able to very quickly complete our validation process.
Dr. Heyko Skladny
Synlab Zentrum für Humangenetik Mannheim
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The varvis® software allows us to very easily process, manage, and interpret our WES data sets. Providing comprehensive annotations and our own proprietary variant knowledgebase, the varvis® software helps us to increase the diagnostic yield and also enables us to make new discoveries.
PD Dr. Silke Kaulfuß
University of Göttingen
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The varvis® software offers a user-friendly interface and very convenient filtering options and convinced us as a reliable and efficient solution for our WES analysis. We are also very satisfied with the dedicated customer support and the training program provided with the varvis® Academy.
Dr. Sandra Fleischer
Gemeinschaftspraxis für Humangenetik & Genetische Labore Hamburg

Schedule your software demo and get a premium free trial including validation

Are you looking for a comprehensive and IVDR-certified software solution for clinical NGS diagnostics? 

Whole exome as a single assay approach, liquid biopsy, carrier screening, automated QC monitoring, validation as a service - we have it all and we‘re ready when you are! Get in touch today and see for yourself. Let‘s navigate the NGS universe together! 


During the varvis® premium trial you can

  • Analyze up to two NGS runs
  • Get detailed QC feedback
  • Review your data in the varvis® software
  • Obtain a validation report
  • Enjoy first-class support